T-2 toxin is hydroxylated by chicken cyp3a37

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August undefined, 2024

WebJan 29, 2024 · T-2 toxin is type A trichothecenes mycotoxin, which produced by fusarium species in cereal grains. T-2 toxin has been shown to induce a series of toxic effects on the health of human and animal, such as immunosuppression and carcinogenesis. Previous study has proven that T-2 toxin caused hepatotoxic … WebSearch life-sciences literature (39,398,388 articles, preprints and more) Search. Quick link: Coronavirus articles and preprints

Activated FXR promotes xenobiotic metabolism of T-2 toxin and ...

WebSep 30, 2013 · T-2 toxin (T-2) is an acute toxic trichothecene mycotoxin produced mainly by Fusarium species, detected in many crops including oats, wheat and barley, in animal feed … WebJan 21, 2016 · T-2 upregulates the expression of CYP1A4 and CYP1A5 in chicken and CYP3A22, CYP3A29 and CYP3A46 in pigs; and these P450 isoforms have been confirmed as the main enzymes for T-2 hydroxylation in vitro. 42, 89–93 T-2 is a CYP1A1 inducer by activating AhR expression in the human intestinal epithelial cell line Caca-2. 94 Recently, … indian land warriors

T-2 toxin is hydroxylated by chicken CYP3A37

WebSep 30, 2013 · Our results showed that chicken CYP3A37 is able to convert T-2 to 3'-OH T-2 with an apparent Km of 15.29 μM, and T-2 hydroxylation activity of CYP3A37 is strongly … WebSep 10, 2024 · T-2 toxin is the most toxic trichothecene mycotoxin, and it exerts potent toxic effects, including immunotoxicity, neurotoxicity, and reproductive toxicity. Recently, … WebOct 1, 2024 · T-2 toxin is a secondary metabolite produced by the Fusarium genus and is highly toxic to both farmed animals and humans. In our previous study, we found that chicken cytochrome P450 1A5 (CYP1A5) can be significantly induced by T-2 toxin in chicken primary hepatocytes and catalyze T-2 toxin into a more toxic product, 3′-OH-T-2. located in the outskirts

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T-2 toxin is hydroxylated by chicken cyp3a37

Metabolism of T-2 toxin by blood cell carboxylesterases

WebT-2 toxin is hydroxylated by chicken CYP3A37 Author: Yuan, Yiyang, Zhou, Xiaojie, Yang, Jiannan, Li, Mei, Qiu, Xinghui Source: Food and chemical toxicology 2013 v.62 pp. 622 … WebAug 15, 1988 · T-2 toxin is hydroxylated by chicken CYP3A37 2013, Food and Chemical Toxicology Citation Excerpt : Hydrolysis, glucuronide conjugation, deepoxidation and hydroxylation are major metabolic reactions in the pathway of T-2 biotransformation (He et al., 2010; Kuca et al., 2008; Li et al., 2011).

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WebMay 5, 2024 · On the basis of characterized functional groups, trichothecenes can be classified into four groups. Type A trichothecenes are mainly represented by T-2 toxins … WebSep 30, 2013 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J

WebT-2 toxin is hydroxylated by chicken CYP3A37 [2013] Yuan, Yiyang; Zhou, Xiaojie; Yang, Jiannan; Li, Mei; et al. Access the full text WebMar 6, 2024 · Yuan Y, Zhou X, Yang J, Li M, Qiu X (2013) T-2 toxin is hydroxylated by chicken CYP3A37. Food Chem Toxicol 62:622–627. CAS Google Scholar Yun Y, Gao T, Li Y, Gao Z, Duan J, Yin H, Duan W (2016) Excretory function of intestinal tract enhanced in kidney impaired rats caused by adenine. Sci World J 16:2695718

WebA single nucleotide polymorphism in the 11th intron was used to assign CYP3A37 to turkey linkage group 10 (corresponding to chicken chromosome 14, GGA14). Because of the important role of P450s in the extreme sensitivity of turkeys to the toxic effects of AFB(1), this study will contribute to the identifying allelic variants of this important ... WebSep 30, 2013 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J

WebDec 1, 2014 · The excellent detection sensitivity in various matrices of T-2 toxin (T-2), which has cytotoxic and immunosuppressive effects in DNA and RNA synthesis, is a highly desirable characteristic. A...

WebT-2 toxin is hydroxylated by chicken CYP3A37. scientific article published on 30 September 2013. Statements. instance of. scholarly article. 1 reference. stated in. Europe PubMed Central. PubMed ID. 24090734. retrieved. indian land warriors footballWebAlthough T-2 toxin occurs naturally in cereal grains, contamination with T-2 toxin is less frequent than with deoxynivalenol (DON). However, T-2 toxin (LD50 in mice: 2–4 mg kg … indian land zip codesWebT-2 toxin (T-2) is an acute toxic trichothecene mycotoxin produced mainly by Fusarium species, detected in many crops including oats, wheat and barley, in animal feed and food. It is important to know the metabolic pathway and kinetics of T-2 in food animals given that T-2 can cause serious adverse effects on human health. In this study, we investigated the … located in the ribosomeWebT-2 toxin is hydroxylated by chicken CYP3A37 [2013] Yuan, Yiyang; Zhou, Xiaojie; Yang, Jiannan; Li, Mei; et al. Access the full text located in the northwest ofWebMay 1, 1985 · Identification of various T-2 toxin metabolites in chicken excreta and tissues. ... T-2 toxin is hydroxylated by chicken CYP3A37. Yuan Y, Zhou X, Yang J, Li M, Qiu X. Food Chem Toxicol, 62:622-627, 30 Sep 2013 Cited by: 11 articles PMID: 24090734. Chicken cytochrome P450 1A5 is the key enzyme for metabolizing T-2 toxin to 3'OH-T-2. ... indian lane durham ctWebDec 1, 2013 · T-2 toxin (T-2) is an acute toxic trichothecene mycotoxin produced mainly by Fusarium species, detected in many crops including oats, wheat and barley, in animal feed … indian land walmart pharmacyWebDec 1, 2024 · Download Citation Activated FXR promotes xenobiotic metabolism of T-2 toxin and attenuates oxidative stress in broiler chicken liver The transmission of T-2 toxin and its metabolites into the ... located in the mediastinum