Rbfox2 is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative splicing in the nervous system and other cell types. Rbfox2 and the related protein Rbfox1 bind to conserved (U)GCAUG RNA motifs in the introns adjacent to many alternatively spliced exons and promotes inclusion or exclusion of the alternative exon in mature transcripts. The protein also interacts with the estrog… WebCell Reports Article Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure Chaoliang Wei,1 Jinsong Qiu,1 Yu Zhou,1 Yuanchao Xue,1 Jing Hu,1 Kunfu Ouyang,2 Indroneal Banerjee,2 Caimei Zhang,4 Biyi Chen,4 Hairi Li,1 Ju Chen,2 Long-Sheng Song,4 and Xiang-Dong Fu1,3,* 1Department of Cellular …
RBFOX2 Gene - GeneCards RFOX2 Protein RFOX2 Antibody
WebNov 12, 2024 · To identify Rbfox2 regulated genes in HCs, ACs and RGCs, we analyzed the retinal transcriptome of Rbfox2 −/− (n = 4) and control (n = 4) animals with RNA-seq. Six … Websplicing via Rbfox1 and Rbfox2 d Rbfox1 and Rbfox2 regulate hundreds of splicing targets in skeletal muscle d Rbfox1 and Rbfox2 loss produces an active and stable isoform of calpain 3 protease d Autophagy flux is markedly decreased in muscle lacking Rbfox1 and Rbfox2 Authors Ravi K. Singh, Arseniy M. Kolonin, Marta L. Fiorotto, Thomas A ... flannel footed pajamas with drop seat
CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast …
WebNov 12, 2024 · Here, we analyzed Rbfox2 expression in adult and developing mouse retinas and the effect of its downregulation on visual function and retinal transcriptome. In adult … WebMay 5, 2024 · The RNA-binding protein RBFOX1 is an important regulator of neuron development and neuronal excitability. Rbfox1 is a dosage-sensitive gene and in both mice and humans, decreased expression of Rbfox1 has been linked to neurodevelopmental disorders. Alternative promoters drive expression of Rbfox1 transcript isoforms that … WebDec 19, 2024 · Paterson and Yu et al. demonstrate that loss of the RNA alternative splicing factor RBFOX2 in the liver during a lipogenic diet leads to dysregulation of liver lipid and cholesterol homeostasis ... can schengen visa convert to work permit