Bivalirudin cardiopulmonary bypass
WebApr 6, 2024 · It is in the direct thrombin inhibitor class of drugs. This activity reviews the indications, action, and contraindications for bivalirudin as a valuable agent in the … Webwe used heparin for cardiopulmonary bypass (CPB) anticoagulation. The baseline celite ACT was 123 seconds and after a heparin dose of 42,000 U (600 U/kg) the celite ACT was 660 seconds. On CPB, in addition to 10,000 U of heparin in the pump FiguRe 1: Heparin concentration. FiguRe 2: Activated clotting time (ACT).
Bivalirudin cardiopulmonary bypass
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WebBACKGROUND: The coronary artery bypass grafting (CABG) heparin-induced thrombocytopenia thrombosis syndrome (HITTS) on- and off-pump safety and efficacy … WebAnesthesia & Analgesia: June 2004 - Volume 98 - Issue 6 - p 1635-1639. doi: 10.1213/01.ANE.0000114072.71353.D5. Free. We treated persistent hemorrhage after cardiopulmonary bypass in a heart transplant recipient who had received anticoagulation with the direct thrombin inhibitor bivalirudin by a combination therapy aimed at reducing …
WebBIVALIRUDIN 1. Pre-VAD implantation work-up (<48 hours pre VAD/MCS): • Baseline labs: CBC with diff, aPTT*, PT/INR, fibrinogen, basic metabolic panel (BMP) • Optional labs: TEG with PM, CRP, LDH, cystatin C, HIT screen, ROTEM 2. Intra-op management • Standard heparin anticoagulation for cardiopulmonary bypass with full WebThe literature on bivalirudin use in children is sparse with case reports of its use during cardiopulmonary bypass, 15 in patients with HIT 16 and in a case series of patients who failed ...
WebBivalirudin is metabolized by intracellular proteolysis, with 20% excreted unchanged by the kidneys. Wolstencroft, Arnold and Anderson present a study using allometry to determine appropriate bivalirudin infusion rates for pediatric patients requiring bivalirudin for cardiopulmonary bypass (CPB) anticoagulation 1. WebJun 19, 2024 · On-pump:Initial bolus: 1 mg/kg, followed by continuous infusion 2.5 mg/kg/hour; 50 mg bolus added to priming solution of cardiopulmonary bypass (CPB) circuit. Additional boluses of 0.1 to 0.5 mg/kg may …
WebFeb 1, 2007 · Background. The coronary artery bypass grafting (CABG) heparin-induced thrombocytopenia thrombosis syndrome (HITTS) on- and off-pump safety and efficacy …
WebBivalirudin was the anticoagulant used during cardiopulmonary bypass. The extracorporeal circuit consisted of a roller pump, a Capiox SX oxygenator (Terumo Cardiovascular Systems, Ann Arbor, MI), and a hard plastic reservoir. birchwood vet clinic prince georgeWebApr 30, 2011 · Extracorporeal membrane oxygenation (ECMO) after cardiac operations (postcardiotomy) is commonly used for the treatment of acute heart failure refractory to drug treatment. Bleeding and thromboembolic events are the most common complications of postcardiotomy ECMO. The present study is a retrospective comparison of the … birch wood vases weddingWebHeparin-induced IgE-mediated hypersensitivity and anaphylactoid reactions, although rare, can pose a serious clinical problem for patients requiring cardiopulmonary bypass … dallas township police paWebHeparin is used to provide anticoagulation during cardiopulmonary bypass, but it has disadvantages including potential development of antiplatelet factor 4/heparin antibodies. A recommended alternative to heparin, bivalirudin, has its own disadvantages including the lack of a reversal agent. Dabigatran may be a better alternative in patients ... dallas township zoning mapWebNov 3, 2010 · Antiphospholipid syndrome (APLS) is a rare syndrome mainly characterized by several hyper-coagulable complications and therefore, implicated in the operated cardiac surgery patient. APLS comprises clinical features such as arterial or venous thromboses, valve disease, coronary artery disease, intracardiac thrombus … birchwood vets companies houseWebInfants with heparin-induced thrombocytopenia (HIT) represent a challenging and high-risk group of patients when they require cardiopulmonary bypass (CPB). Bivalirudin offers many potential pharmacologic advantages over other nonheparin anticoagulants for such patients. We describe our protocol for … birchwood venue spring hill tnWebFeb 1, 2004 · We investigated the use of bivalirudin as an anticoagulant therapy during cardiopulmonary bypass in 20 patients who underwent coronary artery bypass … dallas township zoning ordinance